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Degenerative Myelopathy

This site is dedicated to EXPOSING & Explaining & Eliminating

DEGENERATIVE MYELOPATHY  (DM)

"The silent killer of dogs"

Make Sure You Ask for a DM tested pup or parents!

Some helpful information:

Degenerative Myelopathy (DM)

Description:

Degenerative Myelopathy (DM) is a progressive neurological disorder that affects the spinal cord of dogs. Dogs that have inherited two defective copies will experience a breakdown of the cells responsible for sending and receiving signals from the brain, resulting in neurological symptoms.

The disease often begins with an unsteady gait, and the dog may wobble when they attempt to walk. As the disease progresses, the dog's hind legs will weaken and eventually the dog will be unable to walk at all. Degenerative Myelopathy moves up the body, so if the disease is allowed to progress, the dog will eventually be unable to hold his bladder and will lose normal function in its front legs. Fortunately, there is no direct pain associated with Degenerative Myelopathy.

The onset of Degenerative Myelopathy generally occurs later in life starting at an average age of about 8 years. However, some dogs may begin experiencing symptoms much earlier, some later, and a small percentage of dogs that have inherited two copies of the mutation will not experience symptoms at all. Thus, this disease is not completely penetrant, meaning that while a dog with the mutation is highly likely to develop Degenerative Myelopathy, the disease does not affect every dog that has the genotype.

Test Is Relevant To the Following Breeds:Boxer, Chesapeake Bay Retriever, German Shepherd, Pembroke Welsh Corgi, Cardigan Welsh Corgi, Rhodesian Ridgeback, Poodle, Wire Fox Terrier, Labrador Retriever

Results:Animal Genetics offers DNA testing for Degenerative Myelopathy (DM). The genetic test verifies the presence of the recessive DM mutation and presents results as one of the following:


DM/DMAffectedThe dog has inherited two copies of the mutant gene and is homozygous for DM. There is a strong likelihood that this dog will develop the disorder. The dog will always pass a copy of the mutation to its offspring.DM/nCarrierBoth the normal and mutant copies of the gene detected. The dog is a carrier for DM and could pass on either allele to any offspring 50% of the time.n/nClearDog tested negative for the DM mutation and will not pass on the defective gene to its offspring.

Degenerative Myelopathy Research

Ongoing and Additional Research 

 "Using the DNA test" , it has been identified that there is a mutation that can greatly increase a dog’s risk of developing degenerative myelopathy. They have found that dogs with 2 copies of the mutation (testing “affected” or "at risk") are AT RISK for developing DM at some point in their lives. The age of onset is variable, and there are dogs that test “affected” remain free from symptoms and may die from other causes before ever showing signs of DM. On the other hand, dogs that test “carrier” (one mutant copy and one normal copy) or “clear” (two normal copies) are highly unlikely to develop DM.

Below is a chart showing the results when breeding two dogs with their individual test results of their genotype. 

I took this information from the following website:
   http://www.animalgenetics.us/Canine/Genetic_Disease/DM.asp
   http://www.caninegeneticdiseases.net/DM/resrchDM.htm

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  • HOME
    • Helpful Tips
    • Historic Herder by Joan Hustace Walker
    • Degenerative Myelopathy
    • Spaying and Neutering
    • Potty Training
  • FOR SALE/PUPPIES
    • Upcoming litters
    • Puppies For Sale >
      • Litter by Serenity and Rueben
      • Litter by Fancy and Rueben
    • Adult Dogs for Sale
    • Reviews - Google
    • YELP Reviews
    • Gallery
  • My Dogs
    • Sires/Males >
      • Ammo Von Den Sportwaffen
      • Black Powder Von Der Lieb
      • Ziegfried Zelig Von Majic Forest
    • Dams/Females >
      • Adalia Vom Lieb >
        • Litter by Adalia and Gissmo
        • Born 2/26/17 Adalia & Ziggy
      • Calinda Vom Lieb >
        • 2017 Litter by Ziegfried and Calinda
        • 2016 Litter by Calinda & Ziegfried
        • 2015 Litter by Ziegfried and Calinda
        • 2014 Calinda Vom Lieb and Zeus Von Burton puppies born Sept 2014
      • Litters with outside Females >
        • Litter by Fancy and Ammo
      • KATIE LIEB VOM MAJIC FOREST >
        • 2020 Litter by Katie and Black Powder
        • 2019 Litter by Katie and Black Powder
        • 2018 Litter by Katie and Ammo
      • Leyna Vom Lieb >
        • 2020 Litter by Leyna and Ziggy
        • 2018 Litter by Leyna and Ammo
      • Vom Lieb's Basa Madchen >
        • 2017 Litter by Madchen and Ziggy
        • 2016 Litter by Ziegfried and Madchen
      • Onie Von Delacruz Lieb >
        • Litter by Onie and Ammo
      • Neevahs Night Wind Spirit >
        • 2017 Litter by Ammo and Neevah
        • 2016 Litter by Ammo and Neevah
        • 2014 Czar Winland Vom Kokeltal and Neevahs Night Wind Spirit Puppies Born Nov. 2014
        • 2014 Puppies by Neevah and Kaiser Feb. 2014
      • Royal K9s Remi Vom Haus Galli >
        • 2021 Litter by Astrid and Ammo
        • 2020 Litter by Remi and Ziegfried
        • 2017 Litter by Ziegfried and Remi
        • 2016 Ziegfried and Remi
  • Contact
    • Application
    • Blog
  • Sale Agreement
    • Payment
    • Shipping >
      • Airlines >
        • Airline Flight Check List
      • Transportation by Ground